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Martnez-Reyes, I

While Ipamorelin triggers short GH spikes, CJC-1295 (especially DAC-free) extends GH release duration by stimulating GHRH pathways

These effects were associated with the activation of MAPK signaling, as evidenced by increased phosphorylation of p38, JNK, and ERK1/2, as well as a mitochondria-dependent apoptotic pathway characterized by a reduction in mitochondrial membrane potential

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Most existing studies involve small sample sizes and short duration, limiting generalizability to broader populations