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PLoS One 11 (11), 01661255e166223

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Glutamate accumulation to micromolar levels [375] results in GluN2B-mediated NMDA receptor overactivation, Ca 2+ overload, and subsequent tau hyperphosphorylation and dendritic spine collapse [376], linking excitotoxicity to amyloidogenesis [28]

The findings in this work suggest that SAL0112 exhibits effectiveness comparable to danuglipron and liraglutide in a rodent type 2 diabetes and obesity model and has the potential to offer an improved pharmacokinetic profile in the clinic

Semaglutide: Selective GLP-1 receptor agonist with balanced G protein and beta-arrestin signaling