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Amycretin from Novo Nordisk combines GLP-1 and amylin receptor activation in a single molecule (unlike CagriSema which uses two separate molecules)

Adverse effects observed in trials to date include: Gastrointestinal symptoms nausea, vomiting, diarrhoea, and constipation (common with GLP-1 receptor agonists) Reduced appetite and weight loss , which may be excessive in some individuals Elevated heart rate , a concern noted with glucagon receptor agonism As with other incretin-based therapies, there is also a class-level signal for acute pancreatitis and gallbladder disease (including cholelithiasis and cholecystitis)

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Metabolic acidosis is a rare but serious adverse effect of topiramate due to its carbonic anhydrase inhibitory activity