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4.2 Hyperthyroid-induced hepatic disease Hyperthyroid-induced hepatic disease involves liver injury caused by excessive thyroid hormones, resulting in hepatocellular degeneration, necrosis, and hepatomegaly (106), and often presents with jaundice, elevated transaminases, or cirrhosis (107)

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MOTSc (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded by mitochondrial DNA (mtDNA), not nuclear DNA like most hormones and peptides

doi: 10.1002/jcb.v120.12 95 BenakisCSimatsATritschlerSHeindlSBesson-GirardSLloveraGet al