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Curcumin can also markedly upregulate CD3 - CD19 + CD1d + , CD3 - CD19 + CD25 + , CD3 - CD19 + Foxp3 + Breg cells level and significantly down-regulate CD3 - CD19 + PD-L1 + , CD3 - CD19 + tim-1 + , CD3 - CD19 + CD27 + Breg cells level in DSS-induced colitis mice [264]

The treatment depicted significant telomere extension from 2.4 kb to 4 kb with doses of 0.5 and 1 g /ml in 21NT

Obviously it doesn't replace exercise and a good diet, and only provides a little extra at least for me, but it helps considering the slips in diet derived from our lifestyle

A BCA protein assay kit (Beyotime, China) was used to quantify the protein concentration, and 15-30 g of each sample was separated on 8%-12% SDS-PAGE gels (Beyotime, China)

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