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2019), and it also provides evidence for the deficiency of protease activity in the loss-of-function mutant form of hHPN RS

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There are, however, many limitations associated with these conventional treatments, such as delayed cancer diagnosis, poorly targeted drug delivery, toxic effects, high cost and drug-related side effects [47]

This shift has moved nanotherapeutic design from general exposure modification toward more explicit attempts to match carrier functions with phenotype-specific TME barriers

Membrane-bound lipid peroxidation, driven by LOs and unchecked by GPX4, triggers ferroptosis