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However, all observed effects derive from animal models and in vitro research systems

However, when administered intraperitoneally in vivo , ARC39 showed renal and hepatic toxicity, whereas lower doses, not related to adverse toxic effects, did not influence ceramide content (94)

Aging cell, doi:10.1111/acel.12950 (2019 (in press))

As regards the pathogenic mechanisms, the occurrence of an oxidant stress (resulting from an impaired homocysteine metabolism, which modifies the redox status of extra- and intracellular thiols and thus alters the intracellular redox potential) might play a central role in moderate hyperhomocysteinemia-mediated vascular disorders

(D) Forest plot of primary outcome: subgroup analysis of amyotrophic lateral sclerosis events