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Lactulose to mannitol ratio in humans The ratio of urinary excretion of lactulose to mannitol (LA/MA) was used to measure the intestinal mucosal permeability in ten RA patients and ten healthy controls who underwent colonoscopy, with higher ratios indicative of increased intestinal permeability as previously described 33

For example, after cell stress, p53 interacts with the proapoptotic protein Bak, which promotes the oligomerization of Bak and the release of cytochrome c from mitochondria to induce apoptosis

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