Semaglutide is designed for subcutaneous injection , meaning it belongs in the fatty layer just beneath the skin
Common side effects include nausea, vomiting, diarrhea, constipation, and stomach discomfort, particularly at the start of treatment
This can help reduce any discomfort during the injection
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OA-induced GLP-1 release was significantly inhibited by incubation of cells with U73122 or with the Ca 2+ chelator, BAPTA-AM (78 6 and 82 5% inhibition, respectively), but not with myristoylated PKI (14 8% inhibition) (Figure 5A)