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BPC-157 Body Protection Compound CAS: 137525-51-0 Formula: C 62 H 98 N 16 O 22 M.W.: 1419.556 g/mol Purity: 99%+ Ref No.:BOC-0005VI Ref No.:BOC-0010VI For Research Use Only (RUO) Not for human or veterinary use

N Engl J Med 359(26):28492850

The entry of -KG into the TCA cycle is highly regulated: Pyruvate Dehydrogenase Complex (PDC): The conversion of pyruvate to acetyl-CoA is tightly regulated by the PDC complex, which can be inhibited by acetyl-CoA (feedback inhibition) and activated by ADP

These findings shed light on mechanisms underlying 5FU resistance and propose a rational strategy for combination therapy in CRC, emphasizing the potential clinical benefit of targeting mitochondrial metabolism to overcome resistance and enhance patient outcomes

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