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33823377, 37083708, 36791631) In INH, gyromitra mushroom toxicity, or chronic oral hydralazine use, very high doses are used (e.g., 5 grams IV)

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Patients with pernicious anaemia, malabsorption disorders (such as Crohn's disease or coeliac disease), or following gastric surgery require regular B12 supplementation to prevent serious complications including megaloblastic anaemia and neurological damage

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All human cells can make glutathione, but its production can be inhibited due to a lack of cysteine in the diet