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Preference among clinical studies was given to those with rigorous design and robust analyses, while mechanistic studies were assessed for reproducibility and sound validation

The general consensus is that elevated levels of ammonia and an inflammatory response work in synergy to cause astrocyte to swell and fluid to accumulate in the brain which is thought to explain the symptoms of hepatic encephalopathy

Brit J Cancer 2002;86:1854-7 89 -Neri S ea

Both are administered as weekly subcutaneous injections