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10.2146/ajhp060414 83 KumagaiT.SuzukiH.SasakiT.SakaguchiS.MiyairiS.YamazoeY.et al (2012)

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He is a victim of an unwanted event (Second World War).loss of father made him an isolated, timid and sad child

In normal cells, Nrf2 is kept at low levels in cytoplasm by constitutive synthesis and degradation, which upon activation translocates into the nucleus and binds to the ARE loci