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Chronic inflammatory stimulation in COPD leads to repeated processes of damage and repair in lung tissues, while emphysema, the main pathological manifestation of COPD, is closely linked to the tissue repair function of M2 AMs ( In vivo , chronic pulmonary inflammation resulting from prolonged exposure to CS can induce the highly expressed CD206 and TGF- in macrophages, driving the adaptive immune response of the M2 phenotype to participate in tissue repair (38)