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Interaction between the IVR domain of Keap1 and the NH2-terminal region of CUL3 forms the Keap1-CUL3 complex ( FIGURE 2 Nrf2: The Central node of Keap1-Nrf2 Pathway Nrf2 regulates the induction of the genes related to the generation of NADPH, which is further used by many redox reactions, including malic enzyme 1, 6-phosphogluconate dehydrogenase, isocitrate dehydrogenase 1 and glucose 6-phosphate dehydrogenase ( Nrf2 contains six highly conserved homology domains which are termed Neh1 (Nrf2-ECH homology domain-1) Neh6 (Figure 2)

doi: 10.1007/s11916-004-0022-z 29

In its active form it protects us from free radicals and the damage they can inflict on our cells and DNA

Sid, B., Verrax, J

The drug was easy to get: In drug stores, it could be purchased in unlimited quantities