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Excessive production of ECM components, coupled with chronic inflammation, promotes the progression from steatosis to hepatic fibrosis, cirrhosis, and ultimately liver failure (90)

Ginger extract exhibited the antioxidant effects in IL-1-mediated OS in human C28I2 chondrocyte cells by stimulating the expression of several AOEs, decreasing IL-1-induced ROS production, LPx, and by reducing apoptosis (Bax/Bcl-2 ratio, and caspase-3 activity) (130) ( Supplementary Table 1 )

The bands were assessed by densitometry with Image J software (National Institutes of Health)

The second group includes the organic anion transporting polipeptide proteins OATP which act as GSH/OA- exchanger

Life Sciences, 80(3), 275-284