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While historically listed with an "unknown status," recent data releases in late 2025 and early 2026 have clarified the safety profile that helped justify the Category 1 reclassification. Study Design: A randomized, placebo-controlled, double-blind Phase 1 pilot study

doi: 10.1016/j.ccell.2015.02.006 59 DucrocRSakarYFanjulCBarberABadoAPilar LostaoM

While this is effective as a weight loss strategy, it can also mean you get less nutrients from your diet

Evaluation of publication bias

The combination of training-induced GH release plus peptide-induced GH release creates a multiplicative effect on both fat loss and muscle preservation