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Intrathecal metformin injection significantly reduced methylglyoxal levels and RAGE upregulation in the dorsal horn of the spinal cord in a rat model of BIPN, effectively blocking BTZ-induced central sensitization and mechanical pain abnormalities (Wei et al., 2017)

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Furthermore, supplementary backward citation tracking was performed manually by screening the reference lists of retrieved seminal articles and previous systematic reviews to identify any additional pertinent literature that may have eluded the primary database search

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