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Also, pericytes in the BBB differ from pericytes in the body in their numbers, that is, there is a large number of pericytes located in the CNS compared to other body tissues, thereby making the ratio of pericytes to endothelial cells in the CNS higher (1:1 to 1:3) compared to other cells, such as the muscles (1:100)

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This network upregulates the expression of serine hydroxymethyltransferase-2 ( SHMT2 ) for dTTP synthesis and amino acid transporters, such as solute carrier family 1 member 1 ( SLC1A1 ) and solute carrier family 7 member 8 ( SLC7A8) , for GSH biosynthesis

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