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Degranulated, proteolytically active NSPs are acquired by endothelial cells and cleave endothelial proteins (152), increasing endothelial permeability and injury

Nutraceutical products can be developed from MPs by standardizing their extracts or powders for use in dietary supplements and functional foods

Muscle studies DMD ~150 g/kg

This analgesic effect observed in vivo is likely underlain by liraglutides concerted anti-inflammatory action, as demonstrated in vivo in a mouse model of MIA, whereby liraglutide improves synovitis severity score, and also in vitro , whereby liraglutide dose-dependently decreased PGE 2, nitric oxide (NO), and IL-6 secretion, along with iNos , Cox2 , and Tnf- gene expression levels in both chondrocytes and macrophages