canada tirzepatide (30mg) A new Breakthrough T1D-funded clinical

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Mol Aspects Med 25(56):533549

Chronic hyperglycemia can cause macrovascular complications such as coronary artery disease, peripheral vascular disease, and cerebrovascular disease, and microvascular complications, including retinopathy, nephropathy, and neuropathy [7]

Drug Targets 21 , 884900 (2022)

In addition, reduced SCFA produced by the microbiota leads to inhibition of histone deacetylation and weakened post-translational modification of histones in the gut, which promotes epithelial-mesenchymal transformation (EMT) of renal tubular epithelial cells and participates in renal fibrosis of DN (61)