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While oral formulations offer non-invasive dosing, their low bioavailability and potential gastrointestinal side effects have remained major limitations

When administered intravenously, glutathione achieves significantly higher systemic bioavailability compared to oral supplements, allowing it to effectively inhibit tyrosinasethe enzyme crucial for melanin productionleading to progressive reduction in hyperpigmentation and overall skin brightening

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Third, due to experimental conditions and funding constraints, our study did not use inhibitors of relevant signaling pathways to further validate the mechanism of action of semaglutide