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Before lcFAODs were included in newborn screening (NBS) panels, a considerable number of patients was diagnosed in adulthood and these patients typically presented with different clinical presentations compared to patients who presented during childhood

This senomorphic activity is research-relevant because SASP-driven bystander senescence (neighbouring healthy fibroblasts entering senescence via paracrine SASP signals) is a key driver of progressive dermal ageing and its attenuation by GHK-Cu represents a distinct anti-ageing research mechanism

This strategy provides both targeted local effects and broad systemic support