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The reality is that that what the FDA means by safety is a matter of regulatory compliance (large scale clinical trials, manufacturing standards, etc.) not toxicity

Vomiting occurs in 5 to 12 percent of cases, more commonly at higher doses

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The core mechanism of osteoporosis (imbalance of bone metabolism) Osteoporosis is essentially a negative balance between bone formation and bone resorption, resulting in continuous loss of bone mass, destruction of bone microstructure, increased bone fragility, and increased risk of fractures