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The first hepcidin was identified as an antimicrobial agent in human blood filtrate and denoted LEAP-1 (liver expressed antimicrobial peptide) [154]

CONCLUSIONS GLP-1-RAs were associated with improved survival and fewer complications across stroke subtypes, plus reduced hemorrhagic and ischemic stroke incidence

However, several clinical situations, including insulin-resistant states, PCOS, gestational diabetes, and advanced maternal age, have been associated with reduced tissue myo-inositol concentrations or increased urinary loss, as documented in multiple studies between 2019 and 2024

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Newer uricosuric compounds, such as probenecid, lesinurad and arhalofenate, target different aspects of uric acid metabolism, providing additional options for personalized treatment approaches