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You should contact your GP if you experience: Persistent low mood, sadness, or emptiness lasting more than two weeks Loss of interest or pleasure in activities you previously enjoyed Significant changes in sleep, appetite, or energy levels Difficulty concentrating or making decisions Feelings of worthlessness, excessive guilt, or hopelessness Thoughts of self-harm or suicide For immediate mental health crisis: Call 999 or go to A&E if you or someone else is in immediate danger Contact NHS 111 and select option 2 for urgent mental health support Call the Samaritans free on 116 123 (available 24/7) If you are already taking a GLP-1 agonist and notice mood improvements , this is worth mentioning to your healthcare team, as it may inform your overall treatment plan

41 HansenC.KrychL.NielsenD.VogensenF.HansenL.SrensenS.et al (2012)