Jia Q, Fu Z, Li Y, Kang Z, Wu Y, Ru Z, et al
As telomeres shorten over time, cells lose their ability to function efficiently and eventually stop dividing
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Simhan outlines a multimodal approach to pain management, combining neuropathic pain control, anti-inflammatories, and intraoperative pain blockades rather than relying on opioids alone
The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis later reported 28.7% mean weight loss at 68 weeks with retatrutide 12 mg/week, and identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients (Bays et al., 2025)