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Since receptors for elements such as iron, insulin, and leptin are highly expressed in the lumen, these elements can be transported via RMT [36]

As a key transcription factor for antioxidant stress, NRF2 regulates ferroptosis-related target genes by promoting the expression of those involved in redox homeostasis, such as the glutathione (GSH) synthesis pathway genes (e.g., SLC7A11, SLC3A2, GCLM, and GCLC), which play a critical role in neutralizing ROS and lipid peroxides [31]

Reapply after showering or intense workouts if needed

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