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Three subgenomic RNAs have been identified during the time of host infection, namely I1 sgRNA, I2 sgRNA and LMC-RNA

7 In the Lung Health Study, cough alone (17% of patients) or phlegm alone (12% of patients) were not associated with death, but the combination of cough and phlegm (31% of patients) was associated with increased risk of death after adjustment for covariates (HR 1.27, 95% CI 1.02-1.59)