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The efficacy of bupropion in the treatment of a major depressive episode was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult subjects with MDD [see Clinical Studies (14)]

FDA were scorched by their antidepressant and suicide experience and opted not to put Black Box Warnings on a wide range of drugs such as anticonvulsants which across a range of indications from epilepsy to migraine to mood stabilization had clinical trial data showing increased rates of suicidal events comparable to rates on antidepressants

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