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A GP or specialist can assess whether an individual's medical history, current medications, or underlying conditions make the use of a GLP-1/GIP/glucagon receptor agonist particularly risky

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Ito et al., 2023) (this may be particularly relevant for the destabilization of myelin), synaptic dysfunction (Tu et al., 2014) (this includes impairment of signaling at the axo-myelinic synapse, crucial for survival of the myelinated axon

The nod came nearly eight years after Lonsurf first won approval as a monotherapy for mCRC in Sept