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However, in the pivotal Phase IIb trial, it failed to demonstrate statistically significant weight loss compared to placebo at the primary endpoint, leading the developer (Metabolic Pharmaceuticals Ltd.) to terminate the commercial program

Most clinical studies tracked by the NIH show that patients can lose a significant percentage of their body weight over the first six to twelve months

doi:10.1007/s00405-014-3175-3 Talaat HS, Kabel AM, Khaliel LH, Abuhadied G, El-Naga HA, Talaat AS

These weight-loss drugs also differ in their active ingredients, dosages, potential side effects, and costs