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A study published in the Journal of Biomedical Science and Engineering found that gradual, lifestyle-based weight loss tends to preserve skin integrity more effectively than rapid weight loss associated with GLP-1 medications

In the large SELECT trial , which followed over 17,000 people, semaglutide was found to lower the risk of major heart problems such as heart attack, stroke, and cardiovascular death

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[12] Post-marketing surveillance data from the FDA Adverse Event Reporting System (FAERS) indicate that serious hepatic adverse events with semaglutide are rare, though such spontaneous reporting systems have inherent limitations and cannot establish true incidence or definitive causality

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