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First, these double filters may have more air resistance than a single filter, making the smoke eaters fan work harder to push air through the filter

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The reduction achieved statistical significance in a post-hoc analysis combining the two categories of HNB tobacco smokers

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Low to moderate doses of nicotine reduce the lowest (threshold) stimulation intensity that maintains operant responding for ICSS, reflecting nicotines ability to enhance the reinforcing effects of other stimuli (Kornetsky et al., 1979