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Nicotine is an active ingredient in tobacco that triggers dopamine release and leads to the pleasurable effects of smoking

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However, contrary to popular belief, nicotine is not the primary cause of smoking-related diseases

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In fact, alcohol-use disorders are now the most prevalent of all substance-use disorders worldwide (104), and in 2016, excessive use of alcohol resulted in 3 million deaths, including an estimated 0.4 million deaths from cancers (105)