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Given that mitochondrial dysfunction may be a major source of mitochondrial ROS in COPD, mitochondria-targeted antioxidants may have great therapeutic potential ( 5 Systemic inflammation Patients with COPD, especially during acute exacerbations, are often complicated by systemic inflammation, which often manifests itself in elevated levels of cytokines, chemokines, and inflammatory proteins or abnormal cell counts ( Several studies have identified the presence of potentially pathogenic microorganisms (PPM) in the lower respiratory tract of patients with stable COPD, which may lead to systemic inflammation and increased serum C-reactive protein (CRP), interleukin-8 (IL-8) levels and plasma fibrinogen (FIB) ( In addition to antibiotics, statin is an important intervention for addressing systemic inflammation

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Also, a study by Prietl et al