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5.5 Neurologic Reactions Use of TNF blocking agents, including HUMIRA, has been associated with rare cases of new onset or exacerbation of clinical symptoms and/or radiographic evidence of central nervous system demyelinating disease, including multiple sclerosis (MS) and optic neuritis, and peripheral demyelinating disease, including Guillain-Barr syndrome

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In 1620 the indentured servants were paid for with tobacco, the young women sent to the colonists to become wives were purchased by paying their transportation charges with tobacco