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The original genetic-validation study used antisense oligonucleotide-mediated knockdown of NNMT in adipose tissue of mice on a high-fat diet, with whole-body and adipose-tissue metabolic endpoints measured against scrambled-oligonucleotide controls [2]

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The Phase 3 CagriSema program (REDEFINE 1, 2, REIMAGINE 2) capped cagrilintide at 2.4 mg per week

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Customers should note that BPC-157 research remains primarily preclinical