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If p53 is mutated, unable to function as a transcriptional regulator, and unable to mediate apoptosis, cells can continue to divide without DNA repair, chromosomal damage may occur and magnify with each cell division, and neoplasia can ensue (see Figure 2)

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(b) Significance of the relationship between diets low in saturated fat and cholesterol, and high in fruits, vegetables, and grain products that contain fiber, particularly soluble fiber, and risk of coronary heart disease