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The only respiratory symptom uniquely and consistently associated with EC use in this review is cough, but this may be a transient effect of respiratory irritation, and does not seem to progress into clinically significant lung disease [30]

Keywords: MAPK, FoxA2, cigarette smoke, bronchial epithelial cell, squamous metaplasia Introduction COPD is characterized by irreversible and progressive airflow limitation and encompasses various degrees of chronic obstructive bronchitis and emphysema

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J Clin Psychopharmacol 1981;1:382389