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There may also be minor irritation at the injection site, for example, redness, tenderness, or a brief burning sensation where the NAD+ solution is injected subcutaneously

Limited human observations corroborate a favorable short-term tolerability profile, usually involving mild, transient reactions such as localized injection-site irritation or temporary gastrointestinal discomfort

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for instance, an increase in energy or improvement in mood can often be felt in the first week or two, thanks to the vitamin B in the injection