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Table 1 Characteristics of studies included in the meta-analysis and number of participants with precancerous and cancerous lesions, according to tobacco use Table 2 Quality assessment of studies included in the meta-analysis Statistical analysis Systematic review was conducted using Cochrane Program Review Manager Version 5

again, researchers found no evidence of publication bias or covariate bias

Some of the chemicals in smokeless tobacco products that are known to cause cancer include: Tobacco-specific N-nitrosamines

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Conclusion Tobacco companies have exploited the already established disadvantages of cigarette smoking, especially in pregnancy to drive the popularity of NTPs