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The condition is not dangerous or harmful, but it can be extremely distressing

Proinflammatory cytokines such as IL-1b, IL-6, and TNF-a induce fever, fatigue, anorexia, and cognitive dysfunction

The autoimmune process underlying Hashimoto's disease operates independently of GLP-1 receptor pathways

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However, a drawback of these medicines has been the necessity for administration by subcutaneous injection, which limits patient utilization and may reduce opportunities for fixed-dose combination treatments with other small-molecule drugs