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doi:10.1111/dom.15382 Hegeds L, Sherman SI, Tuttle RM, von Scholten BJ, Rasmussen S, Karsbl JD, et al

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For those with type 2 diabetes, this can delay gastric emptying (which typically leads to an increased feeling of fullness and reduces food intake) and decrease glucagon production (leading to reduced glucose production) when blood sugar levels are elevated

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Tirzepatide slows gastric emptying by activating these neurons, reducing postprandial glucose spikes and attenuating hunger signals relayed to the nucleus tractus solitarius (NTS) [13]