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It is more accurate to call it a dual agonist that includes GLP-1 activity rather than a pure GLP-1 medication

However, she challenges the idea that GLP-1s alone cause this: It does not cause muscle wastingThat is the low-calorie diet that folks end up on when their appetites are crushed out by too high a dose. If you keep a lower dose and ensure people maintain a regular appetite so they can get enough calories and enough protein on board, you could potentially mitigate this side effect, she says

Numerous practice guidelines recommend multicomponent, evidence-based nutritional and behavioral therapy for adults with obesity, but use of such therapies with GLP-1s is not widespread

& Reglinski, J

Diabetes Care 42 , 110118 (2018)