In particular, the irregular activation of the HGF/c-MET pathway enhances the survival of glioma cells via PI3K signaling [11], augments the spread of squamous cell carcinoma through STAT3 signaling [12], promotes the attachment of lymphoma cells via PI3K signaling [13], boosts the growth of head and neck squamous cell carcinoma (HNSCC) through MAPK signaling [14], and triggers EMT and invasion in prostate cancer through Erk/MAPK signaling [15]
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This finding opens up possibilities for therapeutic interventions in neurodegenerative disorders and cognitive decline
Unfortunately, diagnostic accuracy of TNF was only assessed in blood and yielded low specificity and sensitivity, which is unsurprising in light of the discrepancies across studies
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