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All stimuli were presented in a pseudorandom order so that no more than 3 of the same trial types appeared consecutively, with a 1 s response window available for all trials and a variable inter-trial interval (ITI

Ecotoxicology section, 11

So, by silencing the circuit, we were able to demonstrate for certain that this was a very important neural encoder of the behavioral aspect of high-dose nicotine. The only drug designed to help with nicotine cessation, varenicline, could work by increasing aversion via the alpha-7 receptor and lessening desensitization of the alpha-4/beta-2 receptor, she said, but its precise mechanism of action is currently unknown

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