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Similarly, activation of mitochondrial CB 1 Rs with THC resulted in reduced glycolytic activity and lactate production in primary cultured astrocytes (01-days-old), which was hypothesized to contribute to the subsequent impaired neuronal function and altered behavior (e.g., social interaction deficit) in young adult (812-weeks-old) mice (Jimenez-Blasco et al., 2020)

In biochemical and preclinical models, the peptide appears to regulate endothelial activity, cell migration, and cytoskeletal organization through interactions with kinase signaling cascades and nitric oxide related mechanisms

10.1016/j.clinthera.2014.07.017 32 DalbethN.ChoiH

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