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Zepbound severe diarrhea including watery diarrhea, liquid diarrhea, or explosive episodes increases the risk of dehydration and, rarely, acute kidney injury, a complication explicitly noted in the FDA Zepbound prescribing information

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Patients with a history of genital mycotic infections were more likely to have a genital mycotic infection during the trial than those with no prior history (10.0%, 23.1%, and 25.0% versus 0.8%, 5.9%, and 5.0% on placebo, FARXIGA 5 mg, and FARXIGA 10 mg, respectively)

Int J Mol Sci (2020) 21(21):7870

So they turned to another hormone, GIP, which is involved in insulin secretion and blood glucose regulation