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Experiments both in vitro and vivo have shown that metformin attenuates the progression of DKD by suppressing renal inflammation, oxidative stress, and fibrosis (180)

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By suppressing this pathway, natural products like resveratrol, curcumin, and quercetin effectively reduce the bodys production of key inflammatory signals, such as TNF-, IL-6, and IL-1 ( Natural products also exhibit antioxidant effects that reduce oxidative stress by scavenging free radicals, thereby inhibiting inflammation caused by oxidative damage

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